Thermo Fisher Scientific Human CIITA Synthetic Peptide
인간 CIITA 단백질의 N말단 16 아미노산에 해당하는 합성 펩타이드입니다. 폴리클로날 항체 PA5-21031의 블로킹 펩타이드로 사용 가능합니다. 정제된 액상 형태로 제공되며, PBS 버퍼와 0.1% BSA, 0.02% sodium azide를 포함합니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- PEP1145
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 16 amino acids near the amino terminus of human CIITA.
PEP-1145 can be used as a blocking peptide with polyclonal antibody PA5-21031.
Target Information
CIITA contains an acidic transcriptional activation domain, four leucine-rich repeats (LRRs), and a GTP binding domain. It is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex (MHC II) gene transcription, often referred to as the "master control factor" for expression of these genes.
CIITA binds GTP and uses this binding to facilitate its own nuclear transport. Once in the nucleus, it does not bind DNA directly but acts through intrinsic acetyltransferase (AT) activity in a coactivator-like manner.
Mutations in this gene are associated with bare lymphocyte syndrome type II (hereditary MHC class II deficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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