Thermo Fisher Scientific Human NALP12 Synthetic Peptide

Thermo Fisher Scientific Human NALP12 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 18 amino acids near the amino terminus of human NALP12.
PEP-1141 can be used as a blocking peptide with polyclonal antibody PA5-21027.

Target Information

NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and play a crucial role in cell proliferation and reproduction.
NALP12 (also known as Monarch-1) has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD), a NACHT domain, and a NACHT-associated domain.
NALP12 acts as an attenuating factor of inflammation by suppressing NF-kappa-B activation via TLR-signaling molecules such as MyD88, IRAK-1, TRAF6, and RIPK1 in activated monocytes.
Mutations in NALP12 have been linked to hereditary periodic fever syndromes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.