Thermo Fisher Scientific Human NALP12 Synthetic Peptide
Human NALP12 단백질의 N-말단 18개 아미노산 서열을 기반으로 한 합성 펩타이드. Blocking assay에 사용 가능하며, PA5-21027 항체의 대조 또는 차단용으로 적합. 세포 증식 및 염증 반응 연구에 활용되는 연구용 시약.
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Thermo Fisher Scientific Human NALP12 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the amino terminus of human NALP12.
PEP-1141 can be used as a blocking peptide with polyclonal antibody PA5-21027.
Target Information
NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and play a crucial role in cell proliferation and reproduction.
NALP12 (also known as Monarch-1) has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD), a NACHT domain, and a NACHT-associated domain.
NALP12 acts as an attenuating factor of inflammation by suppressing NF-kappa-B activation via TLR-signaling molecules such as MyD88, IRAK-1, TRAF6, and RIPK1 in activated monocytes.
Mutations in NALP12 have been linked to hereditary periodic fever syndromes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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