Thermo Fisher Scientific GPR68 Polyclonal Antibody
Thermo Fisher Scientific의 GPR68 Polyclonal Antibody는 인간 및 생쥐 시료에서 GPR68 단백질을 검출하기 위한 고특이성 항체입니다. Western blot 및 Immunocytochemistry에 적합하며, 액상 형태로 제공됩니다. 연구용으로 pH 감지 수용체 분석에 활용됩니다.
- 카탈로그번호
- PA5118514
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GPR68 (Accession Q15743), corresponding to amino acid residues F194–Y244 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903016 |
Product Specific Information
This antibody detects endogenous levels of total OGR1/GPR68.
Target Information
GPR68 (also known as OGR1 - ovarian cancer G-protein coupled receptor 1) is a proton-sensing receptor involved in pH homeostasis. It acts as an osteoblastic pH sensor regulating cell-mediated response to acidosis in bone. GPR68 mediates its function through G proteins that stimulate inositol phosphate (IP) production or Ca²⁺ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. It also serves as a tumor suppressor in prostate cancer. Mutations in this gene result in amelogenesis imperfecta, hypomaturation type 2A6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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