Thermo Fisher Scientific MERTK Polyclonal Antibody
MERTK 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, ICC, ELISA, IP 등 다양한 응용에 적합합니다. Human, Mouse, Rat 시료에 반응하며, Affinity chromatography로 정제된 고품질 항체입니다. 세포 생존, 분화, 식세포 작용 연구에 활용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 100–200 of MerTK protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MERTK (also known as cMER) is a tyrosine kinase proto-oncogene involved in retinal pigment epithelium (RPE) phagocytosis, which is linked to human retinal disease. It regulates cell survival, migration, differentiation, and efferocytosis (phagocytosis of apoptotic cells). Ligand binding induces autophosphorylation of MERTK, creating docking sites for downstream signaling molecules such as GRB2 and PLCG2, leading to activation of MAPK1, MAPK2, FAK/PTK2, and RAC1 pathways. MERTK signaling is essential for macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization, and suppression of Toll-like receptor (TLR)-mediated immune responses via STAT1 activation, which upregulates SOCS1 and SOCS3 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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