Thermo Fisher Scientific Involucrin Recombinant Rabbit Monoclonal Antibody (8H7B3)
Thermo Fisher Scientific의 Involucrin Recombinant Rabbit Monoclonal Antibody (Clone 8H7B3)는 인볼루크린 단백질 검출용 고특이성 항체입니다. Western blot, IHC, ELISA 등에 적합하며 인간, 마우스, 랫트 시료에 반응합니다. 고순도 정제 및 안정적 액상 형태로 연구용에 최적화되어 있습니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 8H7B3 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 100–200 of human Involucrin (P07476) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911804 |
Product Specific Information
- Positive test controls include: Rat lung.
- Immunogen sequence:
KAENPEQQLK QEKTQRDQQL NKQLEEEKKL LDQQLDQELV KRDEQLGMKK EQLLELPEQQ EGHLKHLEQQ EGQLKHPEQQ EGQLELPEQQ EGQLELPEQQ E
Target Information
Involucrin is a component of the keratinocyte crosslinked envelope, found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. It is expressed in stratified squamous epithelia including the cornea. In normal epidermis, expression begins in the upper spinous layers, and in keratinocyte cultures, it is expressed by cells that have left the basal layer. Abnormal expression occurs in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix. The gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: MA5-42663_Involucrin_P07476-1_Rabbit.svg, MA5-42663_Involucrin_P07476-1_Rabbit_PDP.jpeg)
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