Thermo Fisher Scientific Urotensin II Receptor Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:2,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).

Target Information

The Urotensin-II receptor is highly expressed in the heart and pancreas, as well as in arteries and smooth muscle. Lower transcript levels are found in the brain, particularly in the thalamus and superior occipital gyrus.
G-protein Coupled Receptors (GPCRs) form one of the largest families of signaling molecules, sharing a seven-transmembrane helical structure and existing in active and inactive forms. Ligand binding induces conformational changes leading to G-protein signaling and downstream effects.
GPCR regulation plays a key role in physiological processes and drug discovery, with major pharmaceuticals such as Zyprexa and Claritin targeting GPCR pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.