Thermo Fisher Scientific ARHGEF11 Polyclonal Antibody
ARHGEF11 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, IHC, ICC/IF에 적합하며, 고순도 친화 크로마토그래피 정제 제품입니다. 액상 형태로 -20°C 보관, 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ARHGEF11 (Accession O15085), corresponding to amino acid residues L1432–P1482. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851278 |
Product Specific Information
Antibody detects endogenous levels of total ARHGEF11.
Target Information
ARHGEF11 is a 1527 amino acid protein containing tandem DBL homology and pleckstrin homology domains, a PDZ domain, two proline-rich sequences, and a regulatory G protein-signaling (RGS) sequence.
It functions as a guanine nucleotide exchange factor (GEF) for RhoA GTPase but not for RAC1 or CDC42, and as a GTPase-activating protein (GAP) for GNA12 and GNA13.
ARHGEF11 forms complexes with G proteins and stimulates neurite retraction through Rho-dependent signaling. It increases glutamate transport fourfold, interacts with EAAT4, and modulates uptake activity and perisynaptic distribution at glutamatergic synapses.
Overexpression induces actin cytoskeleton reorganization, membrane ruffling, and filopodia formation. It is ubiquitously expressed in brain, lung, liver, kidney, and skeletal muscle.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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