Thermo Fisher Scientific TRPV6 Polyclonal Antibody

Thermo Fisher Scientific TRPV6 Polyclonal Antibody

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200

Product Specifications

Product Specific Information

• Immunogen sequence: SPHLSLPMPS VSRSTSRSSA NWERLRQGTL RRDLRGIINR GLEDGESWEYQ
• Highest antigen sequence identity to orthologs: Mouse - 82%, Rat - 80%

Target Information

Calcium-permeable channels, such as TRPV6, participate in neurotransmission, muscle contraction, and exocytosis by providing calcium as an intracellular second messenger. Depending on the tissue, transcellular calcium transport may be regulated by vitamin D, parathyroid hormone (PTH), or calcitonin (CALCA).
TRPV6 is a calcium selective cation channel involved in Ca(2+) uptake in various tissues, including intestinal Ca(2+) reabsorption. The channel is activated by low internal calcium levels and exhibits inward rectification.
Inactivation includes both rapid Ca(2+)-dependent and slower Ca(2+)-calmodulin-dependent mechanisms, possibly regulated by phosphorylation. In vitro, it is slowly inhibited by Mg(2+) in a voltage-independent manner.
Heteromeric assembly with TRPV5 modifies channel properties; TRPV5-TRPV6 heteromultimers exhibit voltage-dependent gating. TRPV6 interacts with TRPV5, S100A10, ANAX2-S100A10 heterotetramer, BSPRY, and calmodulin. The interaction with S100A10 is required for trafficking to the plasma membrane.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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