Thermo Fisher Scientific Human/Mouse/Rat Activin A, Animal-Free Recombinant Protein, PeproTech
Human/Mouse/Rat Activin A 재조합 단백질로, E. coli 발현 시스템에서 생산된 동물 유래 성분 없는 고순도(≥97%) 단백질입니다. 세포 증식 억제 활성 검증 완료, ≤2.0 ng/ml의 ED50 보유. 연구용으로 성장 및 분화 연구에 적합합니다.
- 카탈로그번호
- AF-120-14E-xxxxx (3개 옵션)
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
3개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human/Mouse/Rat Activin A, Animal-Free Recombinant Protein, PeproTech
Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Refer to related publications (30 available)
Miscellaneous PubMed (Misc)
- Refer to related publications (3 available)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human, Mouse, Rat |
| Published species | Human, Mouse, Rat |
| Expression System | E. coli |
| Amino Acid Sequence | GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS |
| Molecular Weight | 26 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥97% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | <0.1 EU/µg |
| Activity | Inhibits proliferation of mouse MPC-11 cells; ED50 ≤ 2.0 ng/ml (≥5 × 10⁵ units/mg) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
- Catalog No. AF-120-14E-1MG is supplied as 2 × 500 µg (AF-120-14E-500UG).
- Recombinant Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two betaA chains, each containing 116 amino acid residues.
- Shipped at ambient temperature. For detailed storage, handling, and reconstitution information, refer to the lot-specific Certificate of Analysis.
Target Information
Activins are dimeric growth and differentiation factors belonging to the transforming growth factor-beta (TGF-β) superfamily. They signal through a heteromeric complex of receptor serine kinases, including at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are transmembrane proteins with extracellular ligand-binding domains, transmembrane regions, and cytoplasmic serine/threonine kinase domains.
Type I receptors are essential for signaling, while type II receptors are required for ligand binding and type I receptor expression. Upon ligand binding, type I and II receptors form a stable complex, leading to phosphorylation of type I receptors by type II receptors.
Mutations in Activin A are associated with fibrodysplasia ossificans progressiva.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.