Thermo Fisher Scientific ORC1 Monoclonal Antibody (ORC1 7F6/1)
인간 ORC1 단백질을 인식하는 Mouse IgG1 단일클론 항체입니다. Western blot에 적합하며, 단백질 복제 개시 복합체 연구에 유용합니다. Protein A/G로 정제되었고, 0.76 mg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:100–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ORC1 7F6/1 |
| Immunogen | Bacterially expressed Human ORC1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.76 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2717245 |
Target Information
The origin recognition complex (ORC) is a highly conserved six-subunit protein complex essential for the initiation of DNA replication in eukaryotic cells. Studies in yeast have shown that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. Unlike other ORC subunits that remain stable throughout the cell cycle, the levels of this protein vary and are controlled by ubiquitin-mediated proteolysis after DNA replication initiation. It is selectively phosphorylated during mitosis and interacts with MYST histone acetyltransferase 2 (MyST2/HBO1), which is involved in transcription silencing.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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