Thermo Fisher Scientific Mouse FGF-basic (FGF-2/bFGF), Animal-Free Recombinant Protein, PeproTech

Applications

ELISA (ELISA)

• Tested Dilution: Not specified
• Publications: View 1 publication

Functional Assay (Functional)

• Assay-dependent
• Publications: View publications

In vitro Assay (IV)

• Tested Dilution: Not specified
• Publications: View 46 publications

Miscellaneous PubMed (Misc)

• Tested Dilution: Not specified
• Publications: View 4 publications

Product Specifications

Product Specific Information

Recombinant Murine FGF-basic is a 16.3 kDa protein consisting of 145 amino acid residues.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.

Target Information

FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization.
FGF2 exists as five isoforms with distinct intracellular localizations and functions:

• The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors.
• The 22, 22.5, 24, and 34 kDa isoforms are nuclear and may signal independently of transmembrane receptor pathways.

In humans, the gene is located on the q arm of chromosome 4.
FGF2 plays roles in limb and nervous system development, wound healing, and tumor growth.
The mRNA for FGF2 contains multiple polyadenylation sites and is alternatively translated from non-AUG and AUG initiation codons, resulting in five isoforms with distinct properties.
CUG-initiated isoforms are nuclear (intracrine effect), while AUG-initiated forms are cytosolic (paracrine/autocrine effects).
Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.