Thermo Fisher Scientific CPSF1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Immunogen sequence:
PHWLLVTGRGA LRLHPMAIDG PVDSFAPFHN VNCPRGFLYF NRQGELRISV LPAYLSYDAP WPVRKIPLRC TAHYVAYHVE SKVYAVATST NTPCARIPRM TGEEKEFETI ERDERYIHPQ QEAFSIQLIS PVSWEAIPNA RIELQEWE

Highest antigen sequence identity to the following orthologs:

• Mouse: 96%
• Rat: 96%

Target Information

Midline-1 (Tripartite motif-containing protein 18, Putative transcription factor XPRF, RING finger protein 59) is a 667 amino acid protein encoded by the human gene MID1. Midline-1 belongs to the TRIM/RBCC family and contains two B box-type zinc fingers, one B30.2/SPRY domain, one COS domain, one fibronectin type-III domain, and one RING-type zinc finger.
It is believed to have E3 ubiquitin ligase activity targeting the catalytic subunit of protein phosphatase 2 for degradation. Midline-1 is a cytoplasmic protein found as a homodimer or heterodimer with Midline-2 and interacts with IGBP1 (Lymphocyte signaling protein A4).
Defects in MID1 cause Opitz syndrome type I (OS-I), an X-linked recessive disorder characterized by hypertelorism, genital-urinary defects, lip-palate-laryngotracheal clefts, imperforate anus, developmental delay, and congenital heart defects.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.