Thermo Fisher Scientific Phospho-c-Abl (Tyr272) Polyclonal Antibody
Phospho-c-Abl (Tyr272) 폴리클로날 항체로, Rat, Human, Mouse 시료에 반응합니다. Western blot, IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능하며, 단백질 인산화 연구에 적합합니다. Protein A 정제, 1 mg/mL 농도의 액상 형태로 제공됩니다.
- 카탈로그번호
- BS-4085R
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-c-Abl (Tyr272) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Rat, Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human c-Abl isoform b around the phosphorylation site of Tyr272 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response.
Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of this domain converts c-Abl into an oncogene.
The DNA-binding activity of ABL1 is regulated by CDC2-mediated phosphorylation, suggesting a role in the cell cycle.
In chronic myelogenous leukemia (CML) and some acute lymphoblastic leukemias (ALL), the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation, forming the Philadelphia chromosome, which fuses c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22.
The c-Abl oncogene was first identified as the transforming gene of Abelson murine leukemia virus (A-MuLV).
c-Abl also plays a role in DNA repair by activating proapoptotic pathways when DNA damage is irreparable.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.