Thermo Fisher Scientific THEM4 Polyclonal Antibody
THEM4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, 인간 및 마우스 시료에 반응합니다. Western blot, ICC/IF, ELISA 등 다양한 응용에 적합하며, 고순도 Affinity Chromatography 정제 제품입니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA5110484
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 37–150 of human THEM4 (NP_444283.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.27 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855895 |
Product Specific Information
Immunogen sequence:
SSEEVILKDC SVPNPSWNKD LRLLFDQFMK KCEDGSWKRL PSYKRTPTEW IQDFKTHFLD PKLMKEEQMS QAQLFTRSFD DGLGFEYVMF YNDIEKRMVC LFQGGPYLEG PPGF
Target Information
THEM4 (also known as CTMP) binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells.
Hypermethylation of the THEM4 promoter and transcriptional downregulation have been reported in multiple glioblastomas, suggesting epigenetic regulation may play a role in cancer progression.
Bioinformatic and in vitro analyses indicate THEM4 functions as a broad-range, high-activity acyl-CoA thioesterase.
Recent studies show that overexpression of THEM4 is associated with mitochondrial membrane depolarization and activation of caspase-3 and PARP cleavage, implying involvement in apoptosis.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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