Thermo Fisher Scientific FIS1 Polyclonal Antibody
FIS1 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC 등 다양한 응용에 적합하며 Human, Mouse, Rat 반응성. 고순도 항원 친화 크로마토그래피 정제, 안정적인 액상 형태로 제공.
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Thermo Fisher Scientific FIS1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:20,000 | View 10 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:2,000 | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Full-length human FIS1 recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11152577 |
Product Specific Information
- Recommended positive controls: 293T, A431, HeLa, HepG2, Raji, Mouse brain, Mouse liver, Rat brain
- Predicted reactivity: Mouse (97%), Rat (97%), Rhesus Monkey (100%), Bovine (97%)
Target Information
Fis1 is a 17 kDa integral membrane protein and a key component of mitochondrial fission machinery.
It contains a central leucine-zipper domain, coiled-coil region, tetratricopeptide repeat domain, and a C-terminal transmembrane domain.
Fis1 acts as a pro-apoptotic factor and plays a vital role in mitochondrial fission regulation.
It interacts with DLP1 and Mdv1p, facilitating Dnm1p recruitment to the fission complex, thereby inducing apoptosis.
Fis1 also contributes to peroxisome growth and division. Loss of Fis1 inhibits apoptosis and results in mitochondrial elongation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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