Thermo Fisher Scientific GTF2IRD/TFII-IRD1 Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:100–1:500

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Bovine, Dog, Horse, Pig, Panda, Orangutan, Gorilla, and Chimpanzee

Target Information

Williams-Beuren syndrome (WBS) is a developmental disorder caused by the hemizygous microdeletion on chromosome 7q11.23. WBS is an autosomal dominant genetic condition characterized by physical, cognitive, and behavioral traits. Physical traits include facial dysmorphology, vascular stenoses, growth deficiencies, dental anomalies, and neurologic and musculoskeletal abnormalities. Cognitive and behavioral traits include mild retardation, weakness in visual-spatial skills, anxiety, and short attention span.
The WBSCR11 gene, also designated GRF2IRD1, GTF3, Cream1, and MusTRD1 in human and BEN in mouse, is located within the WBS deletion region and may contribute to developmental symptoms due to loss of the encoded transcription factor. WBSCR11 is expressed in all adult tissues as several variants and shows discrete spatial and temporal expression during embryogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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