Thermo Fisher Scientific SOCS5 Polyclonal Antibody
Thermo Fisher Scientific SOCS5 Polyclonal Antibody는 인간, 마우스, 랫트 반응성을 가진 Rabbit IgG 기반 항체입니다. Western blot에 최적화되어 있으며, SOCS5 단백질의 합성 펩타이드를 면역원으로 사용합니다. 단백질 신호전달 억제 연구용으로 적합합니다.
- 카탈로그번호
- PA141253
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
- View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a portion of human SOCS5 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 100µg/mL BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2193450 |
Product Specific Information
Suggested positive control: human spleen protein, human or mouse spleen, mouse spleen protein.
Target Information
Cytokine receptor signaling is negatively regulated by a family of Src homology 2 (SH2) domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling).
There are eight members of the SOCS family: SOCS-1, 2, 3, 4, 5, 6, 7 and CIS.
SOCS proteins consist of:
- N-terminal region of variable length and amino acid composition
- Central SH2 domain
- C-terminal SOCS box motif
SOCS proteins form a classical negative feedback loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of SOCS genes is rapidly induced by cytokines both in vitro and in vivo. Once produced, SOCS proteins inhibit signaling through various mechanisms.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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