Thermo Fisher Scientific CD47/IAP (Integrin Associated Protein) Monoclonal Antibody (B6H12.2)
인간 CD47 단백질을 인식하는 Mouse IgG1 단클론 항체로, WB, ICC/IF, Flow Cytometry 및 기능적 분석에 사용 가능. 비결합형 액상 형태이며, Protein A/G로 정제됨. 세포 부착 및 신호 전달 연구에 적합.
- 카탈로그번호
- 961-MSM1-P1ABX
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| Functional Assay | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | B6H12.2 |
| Immunogen | Intact CD47 purified from placenta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD47 (Integrin-Associated Protein, IAP) is a ubiquitously expressed cell surface transmembrane glycoprotein that interacts with several integrins and regulates their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, including activation of heterotrimeric G proteins. Functionally, CD47 is involved in increasing intracellular calcium concentration upon cell adhesion to the extracellular matrix.
CD47 also serves as a receptor for the C-terminal cell-binding domain of thrombospondin and may play roles in membrane transport and signal transduction. It has broad tissue distribution and reduced expression on Rh erythrocytes. As a ligand for CD172a (SIRP alpha), CD47 prevents phagocytosis of CD47-positive cells by macrophages. Additionally, the CD47-CD172a system influences cell migration, B cell adhesion, T cell activation, chondrocyte mechanical response modulation, and neuronal development, being especially abundant in synapse-rich brain and retinal regions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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