Thermo Fisher Scientific GFAP Monoclonal Antibody (UMAB5), UltraMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

GFAP (Glial fibrillary acidic protein) is a member of the class III intermediate filament protein family. It is specifically expressed in astrocytes and certain astroglia of the central nervous system, as well as satellite cells of peripheral ganglia and non-myelinating Schwann cells of peripheral nerves.
GFAP serves as a key marker for astrocytic cells and is expressed in various brain tumors derived from astrocytes. It is also found in lens epithelium, Kupffer cells of the liver, certain salivary tumor cells, and erythrocytes.
GFAP helps distinguish astrocytes from other glial cells during development. Mutations in GFAP cause Alexander disease, a rare disorder of astrocytes in the CNS. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.