Thermo Fisher Scientific CD74 Monoclonal Antibody (7C4)

Applications

• Western Blot (WB): 1:1,000

Product Specifications

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons: exon 1 encodes the leader peptide, exons 2 and 3 encode the extracellular domains, and exon 4 encodes the transmembrane domain and cytoplasmic tail. DRA acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5, with no polymorphisms in the peptide-binding region. The beta chain contains polymorphisms determining peptide-binding specificity. Hundreds of DRB1 alleles are known and are routinely typed for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes. The DR, DQ, and DP loci encode the major expressed products of the human class II region. Human MHC class II molecules bind processed peptides, present them to T-helper cells, and play a critical role in initiating immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.