Thermo Fisher Scientific CD45/LCA (Leucocyte Marker) Monoclonal Antibody (2B11, PD7/26)
CD45/LCA 단클론 항체로 모든 핵세포성 혈액세포에서 발현되는 CD45를 검출. Western blot, IHC, Flow cytometry 등 다양한 응용 가능. 단일클론(Mouse IgG1) 형태로 제공되며, PBS buffer에 보존. 연구용으로만 사용.
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- 5788-MSM5-P1ABX
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Thermo Fisher Scientific CD45/LCA (Leucocyte Marker) Monoclonal Antibody (2B11, PD7/26)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Dog, Human |
| Host/Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2B11, PD7/26 |
| Immunogen | Isolated neoplastic cells from T cell lymphoma (2B11) and human peripheral blood lymphocytes maintained in T cell growth factor (PD7/26) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. It is absent on non-hematopoietic cell lines and tissues. CD45 glycoprotein plays a crucial role in lymphocyte development and antigen signaling, acting as a regulator of Src-family kinases. Multiple isoforms exist due to alternative splicing, differing in extracellular domains but sharing identical transmembrane and cytoplasmic regions. CD45RA is one such isoform, showing restricted expression among lymphoid subtypes. CD45 regulates T- and B-cell receptor signaling, suppresses JAK kinases, and modulates integrin-mediated pathways, apoptosis, and immune functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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