Thermo Fisher Scientific IGF1R alpha Monoclonal Antibody (24-60)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:10-1:200

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

-

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

2 µg/mL

View 2 publications 2 publications

ChIP assay (ChIP)

-

View 1 publication 1 publication

Inhibition Assays (IA)

1.5 µg/mL

-

Product Specifications

Published species

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

24-60

Immunogen

IGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10986755

Product Specific Information

MA5-13817 targets IGF-1 Receptor alpha in IA, ICC/IF, WB and IP applications and shows reactivity with Human and Mouse samples.

The MA5-13817 immunogen is iGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA.

Target Information

IGF1R (Insulin-like Growth Factor1 Receptor) is a receptor tyrosine kinase that mediates actions of insulin-like growth factor 1 (IFG1). It binds IGF1 with high affinity and IGF2/insulin with lower affinity. Activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survial of malignant cells. Ligand binding activates the receptor kinase and leads to receptor autophosphorylation and tyrosines phosphorylation of multiple substrates that function as signaling adapter proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.