Thermo Fisher Scientific TRPV2 Polyclonal Antibody
Rabbit polyclonal antibody against human TRPV2, reactive with multiple species. Validated for IHC (Paraffin) at 10 µg/mL. Supplied as liquid, 1 mg/mL, purified by antigen affinity chromatography. Suitable for research on TRPV2 calcium-permeable ion cha...
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Horse, Human, Non-human primate, Pig |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 15 amino acid peptide from N-terminus of human TRPV2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550550 |
Product Specific Information
- Percent identity with other species by BLAST analysis:
- Human, Gorilla, Monkey, Horse, Pig (100%)
- Gibbon, Bovine, Hamster, Panda, Rabbit (93%)
- Mouse, Dog (87%)
- Elephant (80%)
- For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer.
- After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
VLR-1 (also known as TRPV2) is a calcium-permeable, non-selective cation channel with outward rectification. It appears to be regulated by growth factors such as IGF1, PDGF, and morphogenetic neuropeptide/head activator. Unlike other TRP channels, VRL-1 does not respond to capsaicin, acid, or moderate heat, but is activated by high temperatures (~52°C). Within sensory ganglia, VRL-1 is prominently expressed in medium- to large-diameter neurons, suggesting a role in high-threshold heat response. Its expression beyond the sensory nervous system indicates possible activation by stimuli other than heat. VRL-1 is one of six members of the vanilloid-like TRP-channel family, now known as the TRPV family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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