Thermo Fisher Scientific TRPV2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Percent identity with other species by BLAST analysis:
  • Human, Gorilla, Monkey, Horse, Pig (100%)
  • Gibbon, Bovine, Hamster, Panda, Rabbit (93%)
  • Mouse, Dog (87%)
  • Elephant (80%)
• For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer.
• After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Target Information

VLR-1 (also known as TRPV2) is a calcium-permeable, non-selective cation channel with outward rectification. It appears to be regulated by growth factors such as IGF1, PDGF, and morphogenetic neuropeptide/head activator. Unlike other TRP channels, VRL-1 does not respond to capsaicin, acid, or moderate heat, but is activated by high temperatures (~52°C). Within sensory ganglia, VRL-1 is prominently expressed in medium- to large-diameter neurons, suggesting a role in high-threshold heat response. Its expression beyond the sensory nervous system indicates possible activation by stimuli other than heat. VRL-1 is one of six members of the vanilloid-like TRP-channel family, now known as the TRPV family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.