Thermo Fisher Scientific HOXD11 Polyclonal Antibody
Rabbit polyclonal antibody targeting HOXD11 for ICC/IF applications. Recognizes human HOXD11 with high specificity. Supplied as liquid form, unconjugated, purified via antigen affinity chromatography. Suitable for research use only.
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Applications
Immunocytochemistry (ICC/IF)
- Tested dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human HOXD11. Recombinant protein control fragment (Product #RP-106608) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662781 |
Product Specific Information
Immunogen sequence:
FDECGQSAASM YLPGCAYYVA PSDFASKPSF LSQPSSCQMT FPYSSNLAP
Highest antigen sequence identity to the following orthologs:
- Mouse: 98%
- Rat: 98%
Target Information
HOX11, also known as homeobox11 or Tcl-3, is located at the 10q24 T-cell translocation breakpoint region. It encodes a homeobox-domain-containing protein with a glycine- and proline-rich amino terminus. HOX11 is essential for spleen development and cell survival, binding specific DNA sequences and localizing to the nucleus. It acts as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs due to translocations such as t(7;10)(q35;q24) or t(10;14)(q24;q11). These translocations deregulate the gene, leading to activation of tumor-associated target genes and association with T-cell leukemia and lymphoid neoplasias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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