Thermo Fisher Scientific CaMKIV Recombinant Rabbit Monoclonal Antibody (162)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody has specificity for Mouse CaM Kinase 4/CaMKIV.

Target Information

CAMK4 (CaMKIV) is a serine/threonine protein kinase that phosphorylates CREB, oncoprotein 18, and SRF. It has limited tissue distribution and is implicated in transcriptional regulation in lymphocytes, neurons, and male germ cells.

The nuclear localization of this protein supports its role in mediating calcium-dependent gene expression. CaMKIV is abundant in testis, T-cells, and neurons, and also found in other tissues to varying degrees.

In neurons, CaMKIV contributes to synaptic plasticity through gene regulatory effects, while in T-cells, it plays a key role in calcium signaling affecting NFAT. CaMKIV is encoded along with calspermin by the CaMKIV gene and is associated with chromatin in germ cells, suggesting a role in chromatin remodeling during nuclear condensation in spermatids.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.