Thermo Fisher Scientific Phospho-Androgen Receptor (Ser213) Polyclonal Antibody
Phospho-Androgen Receptor (Ser213)에 특이적인 Rabbit Polyclonal Antibody로 인간 시료에 반응. WB, IHC, ICC, ELISA 등 다양한 응용 가능. Protein A로 정제된 액상 형태로 제공되며, 안정적인 저장 버퍼 포함. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human Androgen Receptor around the phosphorylation site of Ser213 [ER(p-S)GA] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It is a ligand-activated transcription factor that binds testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, AR translocates into the nucleus, dimerizes, and activates transcription of androgen-responsive genes. AR signaling is crucial for male reproductive organ development and also functions in muscle, hair follicles, and brain. It is a phosphoprotein involved in MAP kinase regulation, and its phosphorylation state correlates with MEK1/2 pathway activity. Abnormal AR signaling is linked to diseases such as prostate cancer, Kennedy’s disease, and male infertility. Mutations can cause complete androgen insensitivity (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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