Thermo Fisher Scientific CLEC5A Recombinant Rabbit Monoclonal Antibody (005)

Applications and Tested Dilution

• ELISA (ELISA): 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody has specificity for Rat CLEC5A/MDL1/MDL-1.

Target Information

CLEC5A functions as a positive regulator of osteoclastogenesis and acts as a cell surface receptor signaling via TYROBP. It regulates inflammatory responses and plays a key role in synovial injury and bone erosion during autoimmune joint inflammation. CLEC5A also serves as a critical macrophage receptor for dengue virus serotypes 1–4. Binding of dengue virus to CLEC5A triggers TYROBP phosphorylation, leading to proinflammatory cytokine release without viral entry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.