Thermo Fisher Scientific Obinutuzumab Polyclonal Antibody
Obinutuzumab 항원을 인식하는 Rabbit Polyclonal Antibody로, 인간 시료에 반응합니다. ELISA에 최적화되어 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 동결건조 형태로 제공되며, -20°C 이하에서 보관 가능합니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| ELISA | 0.005–1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Obinutuzumab |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/mL.
Obinutuzumab is a humanized anti-CD20 monoclonal antibody, originated by GlycArt Biotechnology AG and developed by Roche as a cancer treatment. It was approved under the trade name Gazyva by the US FDA in 2013, and as Gazyvaro by the EMA in Europe, for the treatment of chronic lymphocytic leukemia in combination with chemotherapy in treatment-naive patients, and as a second-line treatment for follicular lymphoma.
Obinutuzumab binds to CD20 on B cells and causes these cells to be destroyed by engaging the adaptive immune system, directly activating intracellular apoptosis pathways, and activating the complement system.
Target Information
Obinutuzumab is a humanized anti-CD20 monoclonal antibody that binds to an epitope on CD20 partially overlapping with the epitope recognized by rituximab. It induces B-cell destruction through immune system engagement, apoptosis activation, and complement system activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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