Thermo Fisher Scientific FOXL2 Polyclonal Antibody
FOXL2 단백질을 인식하는 염소 유래 폴리클로날 항체로, WB 및 IHC(P) 분석에 적합합니다. 인간과 포유류에서 보존된 FOXL2의 발현 연구에 활용 가능하며, 농도 0.5 mg/mL의 액상 형태로 제공됩니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.3–1 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Bovine |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide DSKTGALHSRLDL, corresponding to amino acids 364–376 of FOXL2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2106202 |
Product Specific Information
- Recommended positive controls: The peptide used to generate this antibody is available for purchase (GTX25096-PEP).
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
FOXL2 is a winged helix/forkhead transcription factor that is highly conserved in human, goat, mouse, and certain aquatic species. It plays a critical role in ovarian differentiation in mammals and in ovarian somatic cell differentiation and follicle development or maintenance. Immunohistochemical data indicate that FOXL2 is a nuclear protein specifically expressed in eyelids and in fetal and adult ovarian follicular cells. It does not undergo major posttranslational modifications. FOXL2 is associated with blepharophimosis/ptosis/epicanthus inversus syndrome (BPES). Type I BPES shows eyelid abnormalities with ovarian failure, while type II BPES involves only eyelid defects. FOXL2 expression has been observed in the mesenchyme of developing mouse eyelids and in adult ovarian follicles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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