Thermo Fisher Scientific CTDSP1 Monoclonal Antibody (OTI1A7), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, an additional desalting step is recommended (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

CTDSP1 is a class 2C phosphatase whose activity depends on the conserved DxD motif. Expression of CTDSP1 inhibits activated transcription from several promoter-reporter constructs, while phosphatase-inactive mutants enhance transcription.
In non-neuronal cells, neuronal gene transcription is repressed by the REST/NRSF complex, which recruits SCPs (including CTDSP1) to RE1-containing genes, leading to silencing.
Loss or inhibition of SCP activity interferes with REST/NRSF function, promoting neuronal differentiation. SCP activity is thus an evolutionarily conserved transcriptional regulator involved in neuronal gene silencing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.