Thermo Fisher Scientific MYLK Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): Tested dilution 1:1,000
• in situ PLA (PLA): Tested dilution 1:1,200

Product Specifications

Product Specific Information

Sequence of MYLK protein is as follows:
MDFRANLQRQ VKPKTVSEEE RKVHSPQQVD FRSVLAKKGT SKTPVPEKVP PPKPATPDFR SVLGGKKKLP AENGSSSAET LNAKAVESSK PLSNAQPSGP LKPVGNAKPA ETLKPMGNAK PAETLKPMGN AKPDENLKSA SKEELKKDVK NDVNCKRGHA GTTDNEKRSE SQGTAPAFKQ KLQDVHVAEG KKLLLQCQVS SDPPATIIWT LNGKTLKTTK FIILSQEGSL CSVSIEKALP EDRGLYKCVA KNDAGQAECS CQVTVDDAPA SENTKAPEMK SRRPKSSLPP VLGTESDATV KKKPAPKTPP KAAMPPQIIQ FPEDQKVRAG ESVELFGKVT GTQPITCTWM KFRKQIQESE HMKVENSENG SKLTILAARQ EHCGCYTLLV ENKLGSRQAQ VNLTVVDKPD PPAGTPCASD IRSSSLTLSW YGSSYDGGSA VQSYSIEIWD SANKTWKELA TCRSTSFNVQ DLLPDHEYKF RVRAINVYGT SEPSQESELT TVGEKPEEPK DEVEVSDDDE KEPEVDYRTV TINTEQKVSD FYDIEERLGS GKFGQVFRLV EKKTRKVWAG KFFKAYSAKE KENIRQEISI MNCLHHPKLV QCVDAFEEKA NIVMVLEIVS GGELFERIID EDFELTEREC IKYMRQISEG VEYIHKQGIV HLDLKPENIM CVNKTGTRIK LIDFGLARRL ENAGSLKVLF GTPEFVAPEV INYEPIGYAT DMWSIGVICY ILVSGLSPFM GDNDNETLAN VTSATWDFDD EAFDEISDDA KDFISNLLKK DMKNRLDCTQ CLQHPWLMKD TKNMEAKKLS KDRMKKYMAR RKWQKTGNAV RAIGRLSSMA MISGLSGRKS STGSPTSPLN AEKLESEEDV SQAFLEAVAE EKPHVKPYFS KTIRDLEVVE GSAARFDCKI EGYPDPEVVW FKDDQSIRES RHFQIDYDED GNCSLIISDV CGDDDAKYTC KAVNSLGEAT CTAELIVETM EEGEGEGEEE EE

Target Information

MYLK (MLCK) is a serine/threonine kinase that phosphorylates myosin regulatory light chains to assist in the production of contractile activity (myosin-actin interaction). MLCK is responsible for smooth muscle contraction via phosphorylation of a specific serine in the N-terminus of myosin light chains (MLC), an event that facilitates myosin interaction with actin filaments.

It plays a central role in vascular permeability and tissue edema formation. In the nervous system, MLCK controls astrocytic process growth and participates in transmitter release at synapses. It is involved in fibroblast apoptosis signaling. Smooth muscle and non-muscle isoforms are widely expressed in adult and fetal tissues. Non-muscle isoform 2 is dominant in various tissues, and the Telokin isoform binds calmodulin. MLCK contains one fibronectin type III domain and nine immunoglobulin-like C2-type domains.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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