Thermo Fisher Scientific TREX1 Polyclonal Antibody, MaxPab
TREX1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot에 최적화되어 있습니다. 인간 단백질에 반응하며, Affinity chromatography로 정제되었습니다. PBS(pH 7.4) 용액 상태로 제공되며, -20°C에서 보관합니다.
- 카탈로그번호
- H00011277-B01P
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | TREX1 (NP_009179, 1 a.a. ~ 304 a.a) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MQTLIFFDME ATGLPFSQPK VTELCLLAVH RCALESPPTS QGPPPTVPPP PRVVDKLSLC VAPGKACSPA ASEITGLSTA VLAAHGRQCF DDNLANLLLA FLRRQPQPWC LVAHNGDRYD FPLLQAELAM LGLTSALDGA FCVDSITALK ALERASSPSE HGPRKSYSLG SIYTRLYGQS PPDSHTAEGD VLALLSICQW RPQALLRWVD AHARPFGTIR PMYGVTASAR TKPRPSAVTT TAHLATTRNT SPSLRESRGT KDLPPVKDPG ALSREGLLAP LGLLAILTLA VATLYGLSLA TPGE
Target Information
Trex1 (ATRIP) is the major human 3' to 5' exonuclease required for checkpoint signaling after DNA damage. It binds to single-stranded DNA coated with replication protein A at sites of DNA damage and recruits ATR, a checkpoint kinase, to these sites. Trex1 is essential for ATR expression and uses two open reading frames encoding proteins involved in DNA damage response and exonuclease activity. Mutations in this gene are associated with Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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