Thermo Fisher Scientific ZDHC3 Polyclonal Antibody
Human ZDHC3 단백질에 특이적인 Rabbit Polyclonal Antibody로, IHC(P)에서 1:50~1:200 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼와 40% 글리세롤에 보관. 골지체 위치 단백질 및 팔미토일화 관련 연구에 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ZDHC3. Recombinant protein control fragment (Product #RP-91170) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2649846 |
Product Specific Information
- Immunogen sequence: FLHCFEEDWT TYGLNREEMA ETGISLHEKM QPLNFSSTEC SSFSPPTT
- Highest antigen sequence identity to orthologs: Mouse - 40%, Rat - 40%
Target Information
Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:19001095, PubMed:21926431, PubMed:22240897, PubMed:23034182, PubMed:22314500).
Plays an important role in G protein-coupled receptor signaling pathways involving GNAQ and other heterotrimeric G proteins by regulating their dynamic association with the plasma membrane (PubMed:19001095).
Palmitoylates ITGA6 and ITGB4, regulating alpha-6/beta-4 integrin localization, expression, and function in cell adhesion to laminin (PubMed:22314500).
Involved in TRAIL-activated apoptotic signaling through palmitoylation and membrane localization of TNFRSF10A (PubMed:22240897).
In the brain, palmitoylates GABRG2 of GABA(A) receptors, influencing synaptic inhibitory function and GABAergic innervation.
Palmitoylates neuronal protein GAP43 involved in GABAergic synapse formation.
Regulates endosome membrane association of NCDN and proper localization of PRCD in photoreceptors.
May mediate palmitoylation of NCAM1, DNAJC5, DLG4, SNAP25, GRIA1, GRIA2, and DRD2 (PubMed:26535572).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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