ELK Biotechnology LIN28A (phospho-Ser200) rabbit pAb

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LIN28A (phospho-Ser200) rabbit pAb

제품 정보

세포 내 위치

Cytoplasm, Rough endoplasmic reticulum, Cytoplasm (P-body), Cytoplasm (Stress granule), Nucleus (nucleolus).
Predominantly cytoplasmic (PubMed:22118463). In the cytoplasm, localizes to peri-endoplasmic reticulum regions and detected in the microsomal fraction derived from rough endoplasmic reticulum (RER) following subcellular fractionation. May be bound to the cytosolic surface of RER on which ER-associated mRNAs are translated (By similarity). Shuttle from the nucleus to the cytoplasm requires RNA-binding (PubMed:17617744). Nucleolar localization is observed in 10–15% of the nuclei in differentiated myotubes (By similarity).

배경(Background)

This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs, which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015]