ELK Biotechnology LRP6 (phospho-Ser1490) rabbit pAb

제품명

LRP6 (phospho-Ser1490) rabbit pAb

공급업체

ELK Biotechnology

제품 개요

이 항체는 인간 LRP6 단백질의 인산화된 Ser1490 부위를 인식하는 rabbit polyclonal antibody입니다. Wnt/β-catenin 신호전달 경로 연구에 유용하며, 세포 분화, 증식 및 암 발생 관련 연구에 적합합니다.

제품 사양

세포 내 위치

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum; Membrane raft.
On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation.
On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD (By similarity).

배경 정보

This gene encodes a member of the low-density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands.
The protein encoded by this gene functions as a receptor or co-receptor (with Frizzled) for Wnt and thereby transmits the canonical Wnt/β-catenin signaling cascade.
Through its interaction with the Wnt/β-catenin signaling cascade, this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types.
This protein undergoes gamma-secretase dependent regulated intramembrane proteolysis (RIP) processing, but the precise locations of the cleavage sites have not been determined. [RefSeq, Dec 2009]