ELK Biotechnology MCM3 (phospho-Ser112) rabbit pAb
MCM3 단백질의 Ser112 인산화 상태를 인식하는 폴리클로날 토끼 항체입니다. WB, ELISA, IHC에 사용 가능하며 인산화 펩타이드를 면역원으로 제작되었습니다. 인간, 쥐, 마우스 시료에 반응하며 핵 내 염색체 관련 단백질 연구에 적합합니다.
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제품명
MCM3 (phospho-Ser112) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | DNA replication licensing factor MCM3 (EC 3.6.4.12); DNA polymerase alpha holoenzyme-associated protein P1; P1-MCM3; RLF subunit beta; p102 |
| Applications | WB, ELISA, IHC |
| Recommended Dilutions | WB: 1:500–2000; IHC-p: 1:50–300; ELISA: 1:2000–20000 |
| Immunogen | Synthesized phospho peptide around human MCM3 (Ser112) |
| Host | Rabbit |
| Storage | −20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 89 kD |
| GeneID (Human) | 4172 |
| Human Swiss-Prot No | P25205 |
| Cellular Localization | Nucleus; Chromosome; Associated with chromatin before nucleus formation and detaches during DNA replication progression |
| Species Reactivity | Human, Rat, Mouse |
배경 정보
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) involved in the initiation of eukaryotic genome replication. The hexameric MCM2–7 complex is a key component of the pre-replication complex (pre_RC), participating in replication fork formation and recruitment of other replication-related proteins.
MCM3 interacts directly with MCM5/CDC46 and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. This acetylation inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been identified for this gene.
[provided by RefSeq, Jul 2012]
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