
ELK Biotechnology MKRN1 rabbit pAb
MKRN1 단백질을 인식하는 토끼 폴리클로날 항체로, WB에 적합합니다. 인간 및 마우스 시료에 반응하며, -20°C에서 1년 보관 가능합니다. 전사 조절 및 단백질 분해 관련 연구에 유용합니다.
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MKRN1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | MKRN1 rabbit pAb |
| Applications | WB |
| Recommended Dilutions | WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human MKRN1 (AA 333–383) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 23608 |
| Human Swiss-Prot No. | Q9UHC7 |
| Species Reactivity | Human, Mouse |
Background
This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. It is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein’s E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21 and p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12, 20, and X. Alternative splicing results in multiple transcript variants encoding different isoforms. (RefSeq, Apr 2014)
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