ELK Biotechnology MLKL (phospho Ser358) rabbit pAb
MLKL (phospho Ser358) rabbit pAb는 인간 MLKL 단백질의 인산화된 Ser358 부위를 인식하는 polyclonal 항체입니다. IHC, IF, WB에 적합하며 necroptosis 연구에 활용됩니다. -20°C에서 1년간 보관 가능합니다.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology MLKL (phospho Ser358) rabbit pAb
제품명
MLKL (phospho Ser358) rabbit pAb
제품 개요
MLKL 단백질은 protein kinase superfamily에 속하며, necroptosis(세포사멸)의 핵심 조절 인자인 RIP3와 상호작용하여 TNF 유도 세포사멸 경로에 관여합니다. 본 항체는 인산화된 Ser358 부위를 인식하도록 제작된 rabbit polyclonal antibody로, necroptosis 관련 신호전달 연구에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | MLKL (phospho Ser358) rabbit pAb |
| Alternative Names | Mixed lineage kinase domain-like protein |
| Applications | IHC, IF, WB |
| Recommended Dilutions | IHC-p: 1:100–500 IF/ICC: 1:100–500 WB: 1:500–2000 |
| Immunogen | Synthesized peptide derived from human MLKL (phospho S358) |
| Species Reactivity | Human |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 55 kD |
| Gene ID (Human) | 197259 |
| Human Swiss-Prot No. | Q8NB16 |
| Cellular Localization | Cytoplasm, Cell membrane, Nucleus. Localizes to cytoplasm and translocates to plasma membrane upon necroptosis induction (PubMed:24316671). Localizes to nucleus in response to orthomyxovirus infection (By similarity). |
| Storage | -20°C, 1 year |
| Host | Rabbit |
Background
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain but is considered inactive due to the lack of several residues required for activity. It plays a critical role in TNF-induced necroptosis via interaction with RIP3, a key signaling molecule in the necroptosis pathway. Inhibitor studies and gene knockdown have shown inhibition of TNF-induced necrosis. High levels of MLKL and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. (RefSeq, Sep 2015)
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.