ELK Biotechnology Mre11 (phospho-Ser676) rabbit pAb
Mre11 단백질의 Ser676 인산화 형태를 인식하는 토끼 폴리클로날 항체. WB, ELISA, IHC에 적합하며, DNA 이중가닥 절단 복구 연구에 활용 가능. 핵 및 염색체 내 국소화. -20°C에서 장기 보관 가능.
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제품명
Mre11 (phospho-Ser676) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Double-strand break repair protein MRE11A (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A) |
| Applications | WB, ELISA, IHC |
| Recommended Dilutions | WB: 1:500–2000; IHC-p: 1:50–300; ELISA: 1:2000–20000 |
| Immunogen | Synthesized phospho peptide around human Mre11 (Ser676) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 80 kDa |
| Gene ID (Human) | 4361 |
| Human Swiss-Prot No. | P49959 |
| Cellular Localization | Nucleus; Chromosome, telomere; Localizes to discrete nuclear foci after treatment with genotoxic agents |
| Species Reactivity | Human, Rat, Mouse |
Background
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. The Mre11 protein exhibits 3′ to 5′ exonuclease and endonuclease activity and forms a complex with RAD50, which is essential for nonhomologous end joining of DNA ends. This complex enhances single-stranded DNA endonuclease and exonuclease activities. Together with a DNA ligase, Mre11 promotes the joining of noncomplementary DNA ends using short homologies near the fragment termini. A pseudogene exists on chromosome 3, and alternative splicing results in two transcript variants encoding distinct isoforms.
(Information provided by RefSeq, Jul 2008)
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