Thermo Fisher Scientific TLX Polyclonal Antibody
TLX 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot과 IHC에 적합. 인간, 마우스, 랫트 반응성. 고순도 친화 크로마토그래피 정제, 1 mg/mL 농도. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
- Publications: [References available]
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- Publications: [References available]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NR2E1 (Accession Q9Y466), corresponding to amino acid residues G141–R191 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852425 |
Product Specific Information
Antibody detects endogenous levels of total NR2E1.
Target Information
Nuclear receptor TLX (NR2 hepatocyte NF4-like receptor) plays a role in anterior brain differentiation, retinal development, and vision. TLX has been shown to regulate genes such as RAR beta2 and Pax2 during retinal development.
Homozygous TLX mutant mice show reduced forebrain development and increased aggression. Deletion of the TLX locus leads to cerebral hypoplasia, blindness, and extreme aggression (fierce phenotype). TLX expression has been documented in mouse brain and eye, and ESTs have been isolated from normal human brain libraries.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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