Thermo Fisher Scientific Peroxiredoxin 4 (Prognostic Marker for Lung SqCC) Monoclonal Antibody (CPTC-PRDX4-2)
인체 PRDX4 단백질을 인식하는 단일클론 항체로 폐 편평상피암 예후 마커 연구에 적합. ELISA 및 면역전기영동에 사용 가능. 단백질 A/G로 정제된 액상 항체로 4°C에서 안정적 보관. 세포 내 및 분비형 PRDX4 검출에 유용.
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Thermo Fisher Scientific Peroxiredoxin 4 (Prognostic Marker for Lung SqCC) Monoclonal Antibody (CPTC-PRDX4-2)
Applications
- ELISA (ELISA): Assay-dependent
- Immunoelectrophoresis (IE): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CPTC-PRDX4-2 |
| Immunogen | Recombinant full-length human PRDX4 protein (UniProt ID: Q13162-1; Range: 1–271) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is stable for 24 months.
- Positive Control: HepG2, HeLa, Jurkat cell lysates; ovarian carcinoma tissue.
- Cellular Localization: Cytoplasm, Secreted.
Specificity Comments:
The peroxiredoxin (PRX) family comprises six antioxidant proteins (PRX I–VI) that protect cells from reactive oxygen species (ROS). These proteins primarily utilize thioredoxin as the electron donor for antioxidation. PRX proteins are involved in cell proliferation, differentiation, and gene expression.
PRX I, II, IV, and VI show diffuse cytoplasmic localization, while PRX III and V are mitochondrial. Human PRX IV is expressed in many tissues and exists as a precursor (testis) and a secreted form. PRX IV is highly expressed in lung cancer and promotes tumor growth in vitro. Its expression correlates with recurrence and shorter disease-free survival in early-stage lung squamous cell carcinoma, making it a useful prognostic marker.
Target Information
Peroxiredoxin (Prx) proteins constitute a peroxidase family associated with cell proliferation, differentiation, and apoptosis. Approximately 50 isoforms exist, characterized by active cysteine residues and thiol-specific antioxidant activity.
Mammalian Prx members are grouped into typical 2-Cys, atypical 2-Cys, and 1-Cys subtypes. Except for Prx VI (1-Cys), the other five 2-Cys Prx isoforms exhibit thioredoxin-dependent peroxidase activity utilizing thioredoxin, thioredoxin reductase, and NADPH.
Mammalian Prxs (20–30 kDa) vary in subcellular localization:
- Prx I, II, VI: Cytosol
- Prx III: Mitochondria
- Prx IV: Endoplasmic reticulum and secreted form
- Prx V: Peroxisome, mitochondria, and cytosol
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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