Thermo Fisher Scientific SOS1 Polyclonal Antibody
Rabbit polyclonal antibody against human SOS1 protein. Validated for Western blot and immunoprecipitation. High specificity and affinity-purified for reliable detection. Supplied as liquid form, 1 mg/mL concentration, stored at 4°C.
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Applications
Western Blot (WB)
- Assay-dependent
Immunoprecipitation (IP)
- 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1025 and 1075 of Human son of sevenless ortholog 1 (SOS1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. Sos1 and its closely related Sos2 paralog contain multiple functional domains, including:
- N-terminal histone-binding domain
- RacGEF catalytic (DH) domain with PH domain
- Ras exchanger motif (REM) domain
- RasGEF catalytic domain
- C-terminal proline-rich region
Sos1 catalyzes GDP–GTP exchange within membrane-bound GTPase Ras, activating the MAPK cascade essential for cellular proliferation, survival, and differentiation. Growth factor stimulation induces phosphorylation of Sos on multiple serine and threonine residues, and phosphorylation at the C-terminus by MAP/ERK kinase disrupts the Grb2–Sos complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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