Thermo Fisher Scientific UFD1L Polyclonal Antibody
Thermo Fisher Scientific의 UFD1L Polyclonal Antibody는 인간, 마우스, 랫트 반응성을 가진 Rabbit IgG 기반 항체입니다. Western blot 및 IHC(P) 실험에 적합하며, 고순도 Protein A 정제 방식으로 제조되었습니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human UFD1L |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Ubiquitin-mediated proteolysis requires the transfer of ubiquitin (Ub) to lysine groups on selected cellular proteins, which then promotes their degradation by the 26S proteasome. Ub-fusions are cleaved by Ub-specific processing proteases (UBps) or by the Ub-fusion degradation (UFD) pathway. The UFD pathway preferentially cleaves Ub-conjugated proteins with amino acid substitutions at the C-terminal glycine residue of Ub.
UFD1 protein, first identified in yeast S. cerevisiae, has a human homolog named UFD1L. In vitro, UFD1 attenuates degradation of Ub-fusions containing proline or valine substitutions at Gly76 by promoting multiubiquitination of the Ub chain. Mutations in the UFD1 gene are linked to CATCH22 syndrome, characterized by cardiac defects, cleft palate, and hypocalcemia, suggesting a role of this pathway in developmental processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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