Thermo Fisher Scientific KDM5B Monoclonal Antibody (1G10)
KDM5B 단백질을 표적으로 하는 Thermo Fisher Scientific의 단클론 항체(1G10)입니다. Western blot 및 ELISA에 적합하며, 인간 시료 반응성을 가집니다. 액상 형태로 제공되며 -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1G10 |
| Immunogen | KDM5B (NP_006609, 231–319 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
AKRMRAEAMN IKIEPEETTE ARTHNLRRRM GCPTPKCENE KEMKSSIKQE PIERKDYIVE NEKEKPKSRS KKATNAVDLY VCLLCGSGN
Target Information
KDM5B is a histone demethylase that demethylates Lys-4 of histone H3, thereby playing a central role in the histone code.
It does not demethylate histone H3 Lys-9 or H3 Lys-27.
KDM5B demethylates trimethylated, dimethylated, and monomethylated H3 Lys-4.
It acts as a transcriptional corepressor for FOXG1B and PAX9.
It favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5.
In contrast, KDM5B may act as a tumor suppressor for melanoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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