Thermo Fisher Scientific DUSP11 Polyclonal Antibody
DUSP11 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며, 합성 펩타이드 면역원으로 제작되었습니다. 액상 형태로 1 mg/mL 농도이며, -20°C에서 보관합니다.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DUSP11 (Accession O75319), corresponding to amino acid residues P54–L104 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815772 |
Product Specific Information
Antibody detects endogenous levels of total DUSP11.
Target Information
DUSP11 (dual specificity phosphatase 11, RNA/RNP complex 1-interacting) is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate target kinases by dephosphorylating both phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.
Different members of the dual specificity phosphatase family show distinct substrate specificities, tissue distribution, subcellular localization, and inducibility by extracellular stimuli. DUSP11 is localized to the nucleus and binds directly to RNA and splicing factors, suggesting a role in nuclear mRNA metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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