Thermo Fisher Scientific Prolactin Receptor Monoclonal Antibody (U5)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA1-610 detects prolactin (PRL) receptor from rat, human, rabbit, horse, and pig tissues.
It has been successfully used in Western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunofluorescence, and FACS procedures.
By Western blot, this antibody detects ~40 kDa and ~100 kDa proteins representing short and long forms of the PRL receptor.
Immunohistochemical staining in rat Islets of Langerhans shows cytoplasmic vesicle staining.
After biotinylation, MA1-610 detects human lymphocyte PRL receptor by FACS.
It does not inhibit prolactin-receptor interaction.
Reconstitute with 100 µL PBS.

Target Information

Prolactin (PRL) is a pituitary hormone involved in milk production, salt and water regulation, growth, development, and reproduction.
PRL acts through a transmembrane PRL receptor initiating signal transduction.
The PRL receptor (PRLR), part of the cytokine receptor family, varies in size from ~40 to 100 kDa depending on tissue and species.
PRLR has three domains: an extracellular region with 5 cysteines containing the prolactin binding site, a single transmembrane domain, and a cytoplasmic region that regulates ligand binding and cellular function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.