Thermo Fisher Scientific Phospho-RNA Polymerase II (Ser2) Polyclonal Antibody
Phospho-RNA Polymerase II (Ser2) 특이적 항체로 인산화된 RNA Pol II CTD를 검출. IHC 및 IHC(Paraffin) 실험에 적합. Rabbit Polyclonal 형식으로 다양한 종에 반응. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 안정성 제공.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Phosphorylated synthetic peptide representing a portion of Human RNA Polymerase II around serine 2 of the C-terminal repeat YSPTSPS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Rat, D. melanogaster, Zebrafish, X. tropicalis, Bovine, Dog, Rabbit, Pig, Panda, Orangutan, Monkey, Gorilla, and Chimpanzee
Target Information
RNA polymerase II is the enzyme responsible for the synthesis of mRNA and many non-coding RNAs.
POLR2A encodes RNA polymerase II subunit B1 (RPB1), the largest subunit of RNA polymerase II.
The C-terminal domain (CTD) of RPB1 contains tandem heptapeptide repeats with the consensus sequence YSPTSPS.
Phosphorylation and other modifications within this sequence influence the recruitment of factors that regulate the transcription cycle.
Recruitment of RNA processing factors to the elongation complex is coordinated by the phosphorylation of Serine-2 and Serine-5 residues within the CTD.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: IHC-00386_RNA_pol_II_CTD_P24928-1_Rabbit.svg, IHC-00386_RNA_pol_II_CTD_P24928-1_Rabbit_PDP.jpeg)
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