Thermo Fisher Scientific GABRA1 Polyclonal Antibody
GABRA1 단백질을 인식하는 Rabbit Polyclonal 항체로 Mouse 및 Rat 시료에 반응. Western blot에 적합하며 항원 친화 크로마토그래피로 정제됨. PBS/glycerol buffer에 보관하며 신경전달 관련 연구에 활용 가능.
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of mouse GABA A Receptor alpha 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.75 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2792900 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (100%), Rat (100%), Rabbit (100%), Chicken (88%), Rhesus Monkey (100%), Bovine (100%).
- Positive Control: mouse brain, rat brain.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing hyperpolarization of the membrane through the opening of a Cl⁻ channel associated with the GABAA Receptor (GABAA-R) subtype.
GABAA-Rs are important therapeutic targets for sedative, anxiolytic, and hypnotic agents and are implicated in diseases such as epilepsy, anxiety, depression, and substance abuse.
The GABAA-R is a multimeric subunit complex; multiple alpha, beta, and gamma subunits and splice variants have been identified. Coexpression of a gamma-subunit is required for benzodiazepine modulation, and phosphorylation of beta-subunits modulates receptor function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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