Thermo Fisher Scientific FK506 Monoclonal Antibody (FK1)

Applications

Tested Dilution

Publications

ELISA (ELISA)

Assay-dependent

-

Product Specifications

Species Reactivity

Chemical

Host/Isotype

Mouse / IgM

Class

Monoclonal

Type

Antibody

Clone

FK1

Immunogen

Conjugate FK-506-BSA

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

4.5 mg/mL

Purification

Euglobulin precipitation, Size-exclusion - Dialysis

Storage buffer

50mM tris/TBS, pH 8.0

Contains

0.09% sodium azide

Storage conditions

4° C, do not freeze

Shipping conditions

Wet ice

RRID

AB_1958006

Product Specific Information

This antibody recognizes conjugated and non-conjugated FK-506 with apparent dissociation constant Kd=10^9M.

Target Information

Tacrolimus is a macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent. [National Center for Biotechnology Information. PubChem Compound Database; CID=445643].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.