Thermo Fisher Scientific IDH1 Monoclonal Antibody (OTI1D1), TrueMAB
IDH1 (mutant R132H) 단백질을 인식하는 단클론 항체로, Western blot 및 IHC(P) 검증 완료. Mouse IgG1 아이소타입, 액상 형태로 제공되며 -20°C에서 보관. 연구용으로 IDH1 변이 검출에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D1 |
| Immunogen | Synthetic peptide around the R132 region of the human IDH conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Isocitrate dehydrogenases such as IDH1 catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses: one utilizing NAD(+) and the other NADP(+).
Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent (mitochondrial matrix) and two NADP(+)-dependent (one mitochondrial, one cytosolic).
The NADP(+)-dependent cytosolic enzyme (IDH1) also localizes to peroxisomes, containing a PTS-1 peroxisomal targeting signal. It plays a key role in regenerating NADPH for peroxisomal reductions and cytoplasmic NADPH production.
This product is specific for IDH1 (mutant R132H).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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